Both Hydroxyzine and Desflurane prolong the QT interval. Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. Increasing age, female sex, cardiac disease, and some metabolic disturbances (notably hypokalaemia) predispose to QT prolongation. Hydroxyzine Tremors, irritability, hyperactivity, jitteriness, shrill cry, myoclonic jerks, hypotonia, increased respiratory and heart rates, feeding problems, clonic movements (mother receiving multiple drug therapy) ... Nonetheless, buprenorphine, either alone (Subutex) or in combination with naloxone (Suboxone), has been used both as a first.